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Discovery of new potentially defective alleles of human CYP2C9.

Pharmacogenetics - 1 Aug 2004

Blaisdell Joyce, Jorge-Nebert Lucia F, Coulter Sherry, Ferguson Stephen S, Lee Su-Jun, Chanas Brian, Xi Tina, Mohrenweiser Harvey, Ghanayem Burhan, Goldstein Joyce A

Abstract excerpt

CYP2C9 is a clinically important enzyme, responsible for the metabolism of numerous clinically important therapeutic drugs. In the present study, we discovered 38 single nucleotide polymorphisms in CYP2C9 by resequencing of genomic DNA from 92 individuals from three different racial groups. Haplotype analysis predicted that there are at least 21 alleles of CYP2C9 in this group of individuals. Six new alleles were...

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PMID: 15284535
DOI: 10.1097/01.fpc.0000114759.08559.51

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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