Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan.

doi:10.1291/hypres.31.1549

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Aug 2008

Yin Tong, Maekawa Keiko, Kamide Kei, Saito Yoshiro, Hanada Hironori, Miyashita Kotaro, Kokubo Yoshihiro, Akaiwa Yasuhisa, Otsubo Ryoichi, Nagatsuka Kazuyuki, Otsuki Toshiho, Horio Takeshi, Takiuchi Shin, Kawano Yuhei, Minematsu Kazuo, Naritomi Hiroaki, Tomoike Hitonobu, Sawada Jun-ichi, Miyata Toshiyuki

Abstract excerpt

CYP2C9, a drug-metabolizing enzyme, converts the angiotensin II receptor blocker losartan to its active form, which is responsible for its antihypertensive effect. We resequenced CYP2C9 in 724 Japanese individuals, including 39 hypertensive patients under treatment with losartan. Of two novel missense mutations identified, the Arg132Gln variant showed a fivefold lower intrinsic clearance toward diclofenac when...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antihypertensive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryl Hydrocarbon Hydroxylases

Share to Crystallography

Share to Cytochrome P-450 CYP2C9

Share to Drug Resistance

Share to Hypertension

Share to Losartan

Share to Mutation, Missense

Source

Open in PubMed

Identifiers

PMID: 18971529
DOI: 10.1291/hypres.31.1549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan.PMID 18971529Read ↗

Substrate-dependent functional alterations of seven CYP2C9 variants found in Japanese subjects.Semantic proximity Read ↗

Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese.Semantic proximity Read ↗

Genetic polymorphisms of CYP2C8 in Japanese population.Semantic proximity Read ↗

Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han populationSemantic proximity Read ↗

Characterization of a novel CYP2C9 mutation (1009C>A) detected in a warfarin-sensitive patient.Semantic proximity Read ↗

In vitro assessment of 36 CYP2C9 allelic isoforms found in the Chinese population on the metabolism of glimepiride.Semantic proximity Read ↗

Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59.Semantic proximity Read ↗

In vitro and in vivo characterization of 13 CYP2C9 allelic variants found in Chinese Han population.Semantic proximity Read ↗

Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics.Semantic proximity Read ↗

Effect of 36 CYP2C9 variants found in the Chinese population on losartan metabolism in vitro.Semantic proximity Read ↗

A systematic genetic polymorphism analysis of the CYP2C9 gene in four different geographical Han populations in mainland China.Semantic proximity Read ↗

Identification and characterization of a novel CYP2C9 allelic variant in a warfarin-sensitive patient.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.