Article
The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2014
Greenbaum Lior, Springer Ramit Ravona, Lutz Michael W, Heymann Anthony, Lubitz Irit, Cooper Itzik, Kravitz Efrat, Sano Mary, Roses Allen D, Silverman Jeremy M, Saunders Ann M, Beeri Michal Schnaider
Abstract excerpt
The variable length poly-T, rs10524523 ('523') located within the TOMM40 gene, was recently associated with several phenotypes of cognitive function. The short (S) allele is associated with later AD onset age and better cognitive performance, compared to the longer alleles (long and very-long (VL)). There is strong linkage disequilibrium between variants in the TOMM40 and APOE genes. In this study, we...
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