A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging.

doi:10.1016/j.neurobiolaging.2015.11.017

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging.

Neurobiology of aging - 1 Mar 2016

Payton A, Sindrewicz P, Pessoa V, Platt H, Horan M, Ollier W, Bubb V J, Pendleton N, Quinn J P

Abstract excerpt

The Translocase of Outer Mitochondrial Membrane 40 Homolog and Apolipoprotein E (TOMM40-APOE) locus has been associated with a number of age-related phenotypes in humans including nonpathologic cognitive aging, late-onset Alzheimer's disease, and longevity. Here, we investigate the influence of the TOMM40 intron 6 poly-T variant (rs10524523) on TOMM40 gene expression and cognitive abilities and decline in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Cohort Studies

Share to Gene Expression Regulation, Developmental

Share to Luciferases

Share to Membrane Transport Proteins

Share to Mitochondrial Precursor Protein Import Complex Proteins

Share to Retroelements

Source

Open in PubMed

Identifiers

PMID: 26742953
DOI: 10.1016/j.neurobiolaging.2015.11.017

Genes

TOMM40
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging.PMID 26742953Read ↗

The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.Semantic proximity Read ↗

The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.Semantic proximity Read ↗

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.Semantic proximity Read ↗

TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.Semantic proximity Read ↗

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.Semantic proximity Read ↗

The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.Semantic proximity Read ↗

An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

Characterization of the poly-T variant in the TOMM40 gene in diverse populations.Semantic proximity Read ↗

TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ε3/ε3.Semantic proximity Read ↗

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.Semantic proximity Read ↗

The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.Semantic proximity Read ↗

Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.