Article
Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.
Cell stem cell - 3 Jul 2014
Suzuki Keiichiro, Yu Chang, Qu Jing, Li Mo, Yao Xiaotian, Yuan Tingting, Goebl April, Tang Senwei, Ren Ruotong, Aizawa Emi, Zhang Fan, Xu Xiuling, Soligalla Rupa Devi, Chen Feng, Kim Jessica, Kim Na Young, Liao Hsin-Kai, Benner Chris, Esteban Concepcion Rodriguez, Jin Yabin, Liu Guang-Hui, Li Yingrui, Izpisua Belmonte Juan Carlos
Abstract excerpt
The utility of genome editing technologies for disease modeling and developing cellular therapies has been extensively documented, but the impact of these technologies on mutational load at the whole-genome level remains unclear. We performed whole-genome sequencing to evaluate the mutational load at single-base resolution in individual gene-corrected human induced pluripotent stem cell (hiPSC) clones in three...
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