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Article

Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9.

Nature protocols - 1 Nov 2016

Park Chul-Yong, Sung Jin Jea, Choi Sang-Hwi, Lee Dongjin R, Park In-Hyun, Kim Dong-Wook

Abstract excerpt

Genome engineering technology using engineered nucleases has been rapidly developing, enabling the efficient correction of simple mutations. However, the precise correction of structural variations (SVs) such as large inversions remains limited. Here we describe a detailed procedure for the modeling or correction of large chromosomal rearrangements and short nucleotide repeat expansions using engineered nucleases...

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Identifiers

PMID: 27711053
DOI: 10.1038/nprot.2016.129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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