Article

Precision genome-editing with CRISPR/Cas9 in human induced pluripotent stem cells

2017-09-12

Abstract excerpt

Genome engineering in human induced pluripotent stem cells (iPSCs) represent an opportunity to examine the contribution of pathogenic and disease modifying alleles to molecular and cellular phenotypes. However, the practical application of genome-editing approaches in human iPSCs has been challenging. We have developed a precise and efficient genome-editing platform that relies on allele-specific guideRNAs (gRNAs)...

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Literature Corpus work: 0fc3a78d-4840-50c8-bbae-7b8563872fcc
DOI: 10.1101/187377

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