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Article

Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions.

Cell stem cell - 7 Jan 2016

Hendriks William T, Warren Curtis R, Cowan Chad A

Abstract excerpt

Human pluripotent stem cells (hPSCs) with knockout or mutant alleles can be generated using custom-engineered nucleases. Transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nucleases are the most commonly employed technologies for editing hPSC genomes. In this Protocol Review, we provide a brief overview of custom-engineered...

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Identifiers

PMID: 26748756
DOI: 10.1016/j.stem.2015.12.002
PMCID: PMC4709030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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