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Article

Efficient and allele-specific genome editing of disease loci in human iPSCs.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2015

Smith Cory, Abalde-Atristain Leire, He Chaoxia, Brodsky Brett R, Braunstein Evan M, Chaudhari Pooja, Jang Yoon-Young, Cheng Linzhao, Ye Zhaohui

Abstract excerpt

Efficient and precise genome editing is crucial for realizing the full research and therapeutic potential of human induced pluripotent stem cells (iPSCs). Engineered nucleases including CRISPR/Cas9 and transcription activator like effector nucleases (TALENs) provide powerful tools for enhancing gene-targeting efficiency. In this study, we investigated the relative efficiencies of CRISPR/Cas9 and TALENs in human...

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PMID: 25418680
DOI: 10.1038/mt.2014.226
PMCID: PMC4351458

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JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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