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Gene editing with 'pencil' rather than 'scissors' in human pluripotent stem cells.

Stem cell research & therapy - 20 Jun 2023

Park Ju-Chan, Park Mihn Jeong, Lee Seung-Yeon, Kim Dayeon, Kim Keun-Tae, Jang Hyeon-Ki, Cha Hyuk-Jin

Abstract excerpt

Owing to the advances in genome editing technologies, research on human pluripotent stem cells (hPSCs) have recently undergone breakthroughs that enable precise alteration of desired nucleotide bases in hPSCs for the creation of isogenic disease models or for autologous ex vivo cell therapy. As pathogenic variants largely consist of point mutations, precise substitution of mutated bases in hPSCs allows...

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PMID: 37340491
DOI: 10.1186/s13287-023-03394-5
PMCID: PMC10283231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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