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An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.

Cell stem cell - 7 Aug 2014

González Federico, Zhu Zengrong, Shi Zhong-Dong, Lelli Katherine, Verma Nipun, Li Qing V, Huangfu Danwei

Abstract excerpt

Human pluripotent stem cells (hPSCs) offer a unique platform for elucidating the genes and molecular pathways that underlie complex traits and diseases. To realize this promise, methods for rapid and controllable genetic manipulations are urgently needed. By combining two newly developed gene-editing tools, the TALEN and CRISPR/Cas systems, we have developed a genome-engineering platform in hPSCs, which we named...

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Identifiers

PMID: 24931489
DOI: 10.1016/j.stem.2014.05.018
PMCID: PMC4127112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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