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Genome editing of human pluripotent stem cells to generate human cellular disease models

1 Jan 2013

Abstract excerpt

Disease modeling with human pluripotent stem cells has come into the public spotlight with the awarding of the Nobel Prize in Physiology or Medicine for 2012 to Drs John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent. This discovery has opened the door for the generation of pluripotent stem cells from individuals with disease and the differentiation of...

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PMID: 23751357
DOI: 10.1242/dmm.012054

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