Article

Genome-Scale CRISPR Screening Identifies Novel Human Pluripotent Gene Networks

2018-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Human pluripotent stem cells (hPSCs) generate a wide variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite the potential of hPSCs, their use for genetic screening has been limited because of technical challenges. We developed a renewable Cas9/sgRNA-hPSC library where loss-of-function mutations can be induced at will. Our inducible-mutant h...

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Literature Corpus work: 63b08944-a8a3-57a1-a042-d5dd9424d754
DOI: 10.1101/323436

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