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CRISPR/Cas9-Mediated Introduction of Specific Heterozygous Mutations in Human Induced Pluripotent Stem Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Brandão Karina O, Grandela Catarina, Yiangou Loukia, Mummery Christine L, Davis Richard P

Abstract excerpt

Advances in genome editing and our ability to derive and differentiate human induced pluripotent stem cells (hiPSCs) into a wide variety of cell types present in the body is revolutionizing how we model human diseases in vitro. Central to this has been the development of the CRISPR/Cas9 system as an inexpensive and highly efficient tool for introducing or correcting disease-associated mutations. However, the ease...

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PMID: 33755904
DOI: 10.1007/7651_2021_368
PMCID: PMC7612905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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