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Article

COMT Associations with Disordered Gambling and Drinking Measures.

Journal of gambling studies - 1 Jun 2015

Guillot Casey R, Fanning Jennifer R, Liang Tiebing, Berman Mitchell E

Abstract excerpt

Disordered gambling and alcohol dependence are influenced by unique and shared genetic factors. Although the evidence is mixed, some research has linked catechol-O-methyltransferase (COMT) rs4680 (or COMT Val158Met) to the development of gambling or drinking problems; however, no molecular genetic study has jointly examined gambling and drinking problems. Furthermore, the majority of past studies examined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24390676
DOI: 10.1007/s10899-013-9434-1
PMCID: PMC4082478

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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COMT Associations with Disordered Gambling and Drinking Measures.PMID 24390676Read ↗

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Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.Semantic proximity Read ↗

Association of the COMT Met¹⁵⁸ allele with trait impulsivity in healthy young adults.Semantic proximity Read ↗

Manic symptom severity correlates with COMT activity in the striatum: A post-mortem study.Semantic proximity Read ↗

Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.Semantic proximity Read ↗

Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial.Semantic proximity Read ↗

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.Semantic proximity Read ↗

Are genetic variants of COMT associated with addiction?Semantic proximity Read ↗

COMT met allele differentially predicts risk versus severity of aberrant eating in a large community sample.Semantic proximity Read ↗

Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study.Semantic proximity Read ↗

Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.Semantic proximity Read ↗

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