Article
Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
Biological psychiatry - 15 Aug 2008
Hettema John M, An Seon-Sook, Bukszar Jozsef, van den Oord Edwin J C G, Neale Michael C, Kendler Kenneth S, Chen Xiangning
Abstract excerpt
BACKGROUND: Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits. METHODS: We examined the COMT gene for association with genetic risk across a range of anxiety spectrum phenotypes. We used multivariate structural equation...
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