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Article

Are genetic variants of COMT associated with addiction?

Pharmacogenetics and genomics - 1 Dec 2010

Tammimäki Anne Emilia, Männistö Pekka T

Abstract excerpt

The human catechol-O-methyl transferase (COMT) gene contains multiple single-nucleotide polymorphisms, some of which are postulated to have clinical significance. This article reviews human studies that have explored the association between COMT polymorphisms and addiction to drugs, alcohol or tobacco. Most studies concentrate on the Val108/158Met polymorphism. Although there are reports indicating a positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 20975619
DOI: 10.1097/FPC.0b013e328340bdf2

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Are genetic variants of COMT associated with addiction?PMID 20975619Read ↗

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The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

[Genetic polymorphism of COMT in mental disorders].Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.Semantic proximity Read ↗

Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders.Semantic proximity Read ↗

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects.Semantic proximity Read ↗

COMT genetic variants and pain.Semantic proximity Read ↗

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