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Article

COMT met allele differentially predicts risk versus severity of aberrant eating in a large community sample.

Psychiatry research - 15 Dec 2014

Donofry Shannon D, Roecklein Kathryn A, Wildes Jennifer E, Miller Megan A, Flory Janine D, Manuck Stephen B

Abstract excerpt

Prefrontal dopamine (DA) transmission participates in the reinforcement of reward-driven behaviors like eating. Because catechol-O-methyltransferase (COMT) degrades DA and is expressed in the prefrontal cortex, variation in the COMT gene may modulate eating behavior. Previous studies have shown t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25216558
DOI: 10.1016/j.psychres.2014.08.037
PMCID: PMC4252581

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25216558-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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