Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study.

Genes, brain, and behavior - 1 Sept 2014

van der Knaap L J, Schaefer J M, Franken I H A, Verhulst F C, van Oort F V A, Riese H

Abstract excerpt

Substance use often starts in adolescence and poses a major problem for society and individual health. The dopamine system plays a role in substance use, and catechol-O-methyltransferase (COMT) is an important enzyme that degrades dopamine. The Val(108/158) Met polymorphism modulates COMT activity and thus dopamine levels, and has been linked to substance use. COMT gene methylation, on the other hand, may affect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alcohol Drinking
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to DNA Methylation

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Smoking

Source

Identifiers

PMID: 24902721
DOI: 10.1111/gbb.12147

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study.PMID 24902721Read ↗

The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.Semantic proximity Read ↗

The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence.Semantic proximity Read ↗

High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers.Semantic proximity Read ↗

Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.Semantic proximity Read ↗

Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.Semantic proximity Read ↗

A COMT gene haplotype associated with methamphetamine abuse.Semantic proximity Read ↗

Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholismSemantic proximity Read ↗

Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers.Semantic proximity Read ↗

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic StudiesSemantic proximity Read ↗

Detection of altered methylation of MB-COMT promotor and DRD2 gene in cannabinoid or synthetic cannabinoid use disorder regarding gene variants and clinical parameters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.