Manic symptom severity correlates with COMT activity in the striatum: A post-mortem study.

doi:10.1080/15622975.2016.1208844

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Article

Manic symptom severity correlates with COMT activity in the striatum: A post-mortem study.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Apr 2017

Bortolato Marco, Walss-Bass Consuelo, Thompson Peter M, Moskovitz Jackob

Abstract excerpt

OBJECTIVES: The enzyme catechol-O-methyltransferase (COMT), which catalyses the degradation of dopamine and norepinephrine, is posited to participate in the pathophysiology of bipolar disorder (BD) and schizophrenia. In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring...

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Identifiers

PMID: 27458023
DOI: 10.1080/15622975.2016.1208844
PMCID: PMC5468118

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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