Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.

doi:10.1038/sj.npp.1300997

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Article

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2006

Beuten Joke, Payne Thomas J, Ma Jennie Z, Li Ming D

Abstract excerpt

The catechol-O-methyltransferase (COMT) gene plays a prominent role in dopaminergic circuits central to drug reward. Allelic variants within the COMT gene are therefore potential candidates for examining interindividual differences in vulnerability to nicotine dependence (ND). We analyzed five single nucleotide polymorphisms (SNPs), including the Val/Met variant (rs4680), which results in a three- to four-fold...

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PMID: 16395295
DOI: 10.1038/sj.npp.1300997

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COMT

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