Article
Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2008
Lohoff Falk W, Weller Andrew E, Bloch Paul J, Nall Aleksandra H, Ferraro Thomas N, Kampman Kyle M, Pettinati Helen M, Oslin David W, Dackis Charles A, O'Brien Charles P, Berrettini Wade H
Abstract excerpt
Dopaminergic brain systems have been documented to have a major role in drug reward, thus making genes involved in these circuits plausible candidates for susceptibility to substance use disorders. The catechol-O-methyltransferase (COMT) is involved in the degradation of catecholamines and a functional polymorphism (Val158Met) has been suggested to influence enzyme activity. In this study we hypothesize that...
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