Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.

doi:10.1002/ajmg.b.30831

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Article

Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2009

Halleland H, Lundervold A J, Halmøy A, Haavik J, Johansson S

Abstract excerpt

It has been suggested that symptoms of attention-deficit/hyperactivity disorder (ADHD) is related to low dopamine levels in the prefrontal cortex. The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680) polymorphism in ADHD have been inconsistent. However,...

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Identifiers

PMID: 18802928
DOI: 10.1002/ajmg.b.30831

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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