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Article

Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial.

Human genetics - 1 Aug 2007

Wang Sophia S, Morton Lindsay M, Bergen Andrew W, Lan Elizabeth Z, Chatterjee Nilanjan, Kvale Paul, Hayes Richard B, Chanock Stephen J, Caporaso Neil E

Abstract excerpt

Catechol-O-methyltransferase (COMT) is an important modulator in the catabolism of extraneural dopamine, which plays an important role in drug reward mechanisms. It is hypothesized that genetic variations in the COMT gene, which can result in a three to fourfold difference in COMT enzyme activity, may be associated with several reward-motivated behaviors. The aim of our study was to examine the relationship...

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Source

Identifiers

PMID: 17497175
DOI: 10.1007/s00439-007-0374-7

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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