Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.

The international journal of neuropsychopharmacology - 1 Apr 2011

Nedic Gordana, Nikolac Matea, Sviglin Korona Nenadic, Muck-Seler Dorotea, Borovecki Fran, Pivac Nela

Abstract excerpt

Alcohol dependence is frequently associated with aggressive and suicidal behaviour. Genetic factors contribute to both behaviours. Candidate genes, related to suicide and aggression, include genes involved in serotonin, norepinephrine and dopamine pathways. The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine. The functional polymorphism (COMT Val108/158Met) affects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggression
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Depression

Share to Mental Disorders

Share to Methionine

Share to Suicide, Attempted

Share to Valine

Source

Identifiers

PMID: 20860878
DOI: 10.1017/S1461145710001057

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.PMID 20860878Read ↗

The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide.Semantic proximity Read ↗

Association between catechol-O-methyltransferase functional polymorphism and male suicide completers.Semantic proximity Read ↗

Val158Met COMT polymorphism and risk of aggression in alcohol dependence.Semantic proximity Read ↗

Association between Catechol-O-Methyltransferase Val158Met (158G/A) Polymorphism and Suicide Susceptibility: A Meta-analysis.Semantic proximity Read ↗

A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits.Semantic proximity Read ↗

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic StudiesSemantic proximity Read ↗

No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders.Semantic proximity Read ↗

Association study of Catechol-O-Methyltransferase (COMT) rs4680 Val158Met gene polymorphism and suicide attempt in Mexican adolescents with major depressive disorder.Semantic proximity Read ↗

Association of gene polymorphisms encoding dopaminergic system components and platelet MAO-B activity with alcohol dependence and alcohol dependence-related phenotypes.Semantic proximity Read ↗

Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior.Semantic proximity Read ↗

Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.Semantic proximity Read ↗

Gender effect of catechol-O-methyltransferase Val158Met polymorphism on suicidal behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.