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Article

The replication initiation protein Sld2 regulates helicase assembly.

The Journal of biological chemistry - 24 Jan 2014

Bruck Irina, Kaplan Daniel L

Abstract excerpt

Assembly of the Cdc45-Mcm2-7-GINS (CMG) replicative helicase complex must be regulated to ensure that DNA unwinding is coupled with DNA synthesis. Sld2 is required for the initiation of DNA replication in budding yeast. We identified a mutant of Sld2, Sld2-m1,4, that is specifically defective in Mcm2-7 binding. When this sld2-m1,4 mutant is expressed, cells exhibit severe inhibition of DNA replication....

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Identifiers

PMID: 24307213
DOI: 10.1074/jbc.M113.532085
PMCID: PMC3900945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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