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Article

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.

Nucleic acids research - 7 Sept 2021

Shastri Vivek M, Subramanian Veena, Schmidt Kristina H

Abstract excerpt

The Bloom syndrome DNA helicase BLM contributes to chromosome stability through its roles in double-strand break repair by homologous recombination and DNA replication fork restart during the replication stress response. Loss of BLM activity leads to Bloom syndrome, which is characterized by extraordinary cancer risk and small stature. Here, we have analyzed the composition of the BLM complex during unperturbed...

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Identifiers

PMID: 34370039
DOI: 10.1093/nar/gkab663
PMCID: PMC8421143

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