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Article

Uninterrupted MCM2-7 function required for DNA replication fork progression.

Science (New York, N.Y.) - 2 Jun 2000

Labib K, Tercero J A, Diffley J F

Abstract excerpt

Little is known about the DNA helicases required for the elongation phase of eukaryotic chromosome replication. Minichromosome maintenance (MCM) protein complexes have DNA helicase activity but have only been functionally implicated in initiating DNA replication. Using an improved method for constructing conditional degron mutants, we show that depletion of MCMs after initiation irreversibly blocks the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10834843
DOI: 10.1126/science.288.5471.1643

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uninterrupted MCM2-7 function required for DNA replication fork progression.PMID 10834843Read ↗

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How MCM loading and spreading specify eukaryotic DNA replication initiation sitesSemantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

DONSON is required for CMG helicase assembly in the mammalian cell cycleSemantic proximity Read ↗

The MCM Complex: Its Role in DNA Replication and Implications for Cancer TherapySemantic proximity Read ↗

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.Semantic proximity Read ↗

Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.Semantic proximity Read ↗

Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.Semantic proximity Read ↗

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