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Article

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.

Genes & development - 15 Dec 1997

Lei M, Kawasaki Y, Young M R, Kihara M, Sugino A, Tye B K

Abstract excerpt

The initiation of DNA synthesis is an important cell cycle event that defines the beginning of S phase. This critical event involves the participation of proteins whose functions are regulated by cyclin dependent protein kinases (Cdks). The Mcm2-7 proteins are a family of six conserved proteins that are essential for the initiation of DNA synthesis in all eukaryotes. In Saccharomyces cerevisiae, members of the...

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Identifiers

PMID: 9407029
DOI: 10.1101/gad.11.24.3365
PMCID: PMC316824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.PMID 9407029Read ↗

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.Semantic proximity Read ↗

Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.Semantic proximity Read ↗

Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain.Semantic proximity Read ↗

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.Semantic proximity Read ↗

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.Semantic proximity Read ↗

Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein.Semantic proximity Read ↗

Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.Semantic proximity Read ↗

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p.Semantic proximity Read ↗

Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.Semantic proximity Read ↗

Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.Semantic proximity Read ↗

Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4Semantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

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