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Article

CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans.

The Journal of cell biology - 17 Feb 2014

Gaggioli Vincent, Zeiser Eva, Rivers David, Bradshaw Charles R, Ahringer Julie, Zegerman Philip

Abstract excerpt

Cyclin-dependent kinase (CDK) plays a vital role in proliferation control across eukaryotes. Despite this, how CDK mediates cell cycle and developmental transitions in metazoa is poorly understood. In this paper, we identify orthologues of Sld2, a CDK target that is important for DNA replication in yeast, and characterize SLD-2 in the nematode worm Caenorhabditis elegans. We demonstrate that SLD-2 is required for...

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Identifiers

PMID: 24535824
DOI: 10.1083/jcb.201310083
PMCID: PMC3926958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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