Article

DONSON is required for CMG helicase assembly in the mammalian cell cycle

2023-08-17

Abstract excerpt

DONSON is one of 13 genes mutated in a form of primordial microcephalic dwarfism known as Meier-Gorlin Syndrome. The other 12 encode components of the CDC45-MCM-GINS helicase, around which the eukaryotic replisome forms, or are factors required for helicase assembly during DNA replication initiation. A role for DONSON in CDC45-MCM-GINS assembly was unanticipated, since DNA replication initiation can be reconstitut...

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Literature Corpus work: 55a8d3dc-06a2-5496-ab20-f1ab3e5729cd
DOI: 10.1101/2023.08.16.553614

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DONSON is required for CMG helicase assembly in the mammalian cell cycleDOI 10.1101/2023.08.16.553614Read

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