Article

MCM10 and SLD-2/RECQL4 jointly activate the CMG helicase during metazoan DNA replication initiation

2026-04-02

Abstract excerpt

Eukaryotic cells regulate the assembly and activation of the essential DNA helicase at the heart of the chromosome replication machinery, to ensure that the chromosomes are copied just once per cell cycle. The Mcm10 protein is essential for helicase activation in budding yeast, but an equivalent role for MCM10 orthologues in animal cells has not been explored. Moreover, complete deletion of the mcm-10 gene is via...

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Literature Corpus work: df9741d3-76fd-5b6e-9ea4-b4b7a2c4573a
DOI: 10.64898/2026.04.01.715773

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