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Article

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

Genes & development - 15 Apr 2000

Homesley L, Lei M, Kawasaki Y, Sawyer S, Christensen T, Tye B K

Abstract excerpt

MCM2-7, a complex of six subunits, is an essential component of the prereplication chromatin that is assembled at Saccharomyces cerevisiae replication origins during G(1) phase. It is also believed to be the processive helicase at growing forks. To elucidate the action of MCM2-7 during the transition from initiation to elongation replication, we have focused our studies on Mcm10, a replication initiation protein...

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Share to Cell Cycle
Share to Chromatin
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to G1 Phase

Share to Minichromosome Maintenance Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 10783164
PMCID: PMC316538

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.PMID 10783164Read ↗

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The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.Semantic proximity Read ↗

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