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Article

The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.

Genes & development - 1 Apr 2004

Pappas Donald L, Frisch Ryan, Weinreich Michael

Abstract excerpt

The establishment of DNA synthesis during the S phase is a multistep process that occurs in several stages beginning in late mitosis. The first step is the formation of a large prereplicative complex (pre-RC) at individual replication origins and occurs during exit from mitosis and entry into G1 phase. To better understand the genetic requirements for pre-RC formation, we selected chromosomal suppressors of a...

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Identifiers

PMID: 15082529
DOI: 10.1101/gad.1173204
PMCID: PMC387417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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