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Article

High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8.

PLoS genetics - 1 Aug 2013

Aristizabal Maria J, Negri Gian Luca, Benschop Joris J, Holstege Frank C P, Krogan Nevan J, Kobor Michael S

Abstract excerpt

The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction, chromatin immunoprecipitation followed by microarrays (ChIP-on-chip) and mRNA expression analysis, we found that truncating the CTD resulted in distinct changes to cellular function. Truncating the CTD altered RNAPII occupancy, leading to...

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Share to Chromatin Immunoprecipitation
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Protein Structure, Tertiary

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Transcription, Genetic

Source

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Identifiers

PMID: 24009531
DOI: 10.1371/journal.pgen.1003758
PMCID: PMC3757075

Genes

CDK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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