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Article

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.

Molecular cell - 4 Jan 2018

Shah Nilay, Maqbool Muhammad Ahmad, Yahia Yousra, El Aabidine Amal Zine, Esnault Cyril, Forné Ignasi, Decker Tim-Michael, Martin David, Schüller Roland, Krebs Stefan, Blum Helmut, Imhof Axel, Eick Dirk, Andrau Jean-Christophe

Abstract excerpt

The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is composed of a repetition of YSPTSPS heptads and functions as a loading platform for protein complexes that regulate transcription, splicing, and maturation of RNAs. Here, we studied mammalian CTD mutants to analyze the function of tyrosine1 residues in the transcription cycle. Mutation of 3/4 of the tyrosine residues (YFFF mutant) resulted in a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29304333
DOI: 10.1016/j.molcel.2017.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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