Article
Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain.
BMC research notes - 29 Oct 2015
Pineda Gabriel, Shen Zhouxin, de Albuquerque Claudio Ponte, Reynoso Eduardo, Chen Jeffrey, Tu Chi-Chiang, Tang Wingchung, Briggs Steve, Zhou Huilin, Wang Jean Y J
Abstract excerpt
BACKGROUND: Eukaryotic RNA polymerase II contains a C-terminal repeated domain (CTD) consisting of 52 consensus heptad repeats of Y1S2P3T4S5P6S7 that mediate interactions with many cellular proteins to regulate transcription elongation, RNA processing and chromatin structure. A number of CTD-binding proteins have been identified and the crystal structures of several protein-CTD complexes have demonstrated...
Topics
- Amino Acid Sequence
- Binding Sites
- Cell Cycle Proteins
- Gamma Rays
- Gene Expression Regulation
- HeLa Cells
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Peptides
- Phosphorylation