Article

Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5’- and 3’-ends

2025-01-09

Abstract excerpt

<h4>SUMMARY</h4> CDK7 regulates RNA polymerase II (RNAPII) initiation, elongation, and termination through incompletely understood mechanisms. Because contaminating kinases precluded CDK7 analysis with nuclear extracts, we completed biochemical assays with purified factors. Reconstitution of RNAPII transcription initiation showed CDK7 inhibition slowed and/or paused RNAPII promoter-proximal transcription, which r...

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Literature Corpus work: eac3db59-3cb5-52dc-a650-25578eabb699
DOI: 10.1101/2025.01.08.632016

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Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5’- and 3’-endsDOI 10.1101/2025.01.08.632016Read

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