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Article

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.

Genes & development - 1 Oct 2011

Blattner Claudia, Jennebach Stefan, Herzog Franz, Mayer Andreas, Cheung Alan C M, Witte Gregor, Lorenzen Kristina, Hopfner Karl-Peter, Heck Albert J R, Aebersold Ruedi, Cramer Patrick

Abstract excerpt

Cell growth is regulated during RNA polymerase (Pol) I transcription initiation by the conserved factor Rrn3/TIF-IA in yeast/humans. Here we provide a structure-function analysis of Rrn3 based on a combination of structural biology with in vivo and in vitro functional assays. The Rrn3 crystal structure reveals a unique HEAT repeat fold and a surface serine patch. Phosphorylation of this patch represses human Pol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21940764
DOI: 10.1101/gad.17363311
PMCID: PMC3197207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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