Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pin1 modulates RNA polymerase II activity during the transcription cycle.

Genes & development - 15 Nov 2007

Xu Yu-Xin, Manley James L

Abstract excerpt

The C-terminal domain of the RNA polymerase (RNAP) II largest subunit (CTD) plays a critical role in coordinating multiple events in pre-mRNA transcription and processing. Previously we reported that the peptidyl prolyl isomerase Pin1 modulates RNAP II function during the cell cycle. Here we provide evidence that Pin1 affects multiple aspects of RNAP II function via its regulation of CTD phosphorylation. Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Chromatin
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to HeLa Cells

Share to NIMA-Interacting Peptidylprolyl Isomerase

Share to Peptidylprolyl Isomerase

Share to RNA Polymerase II

Source

Open in PubMed Open full text

Identifiers

PMID: 18006688
DOI: 10.1101/gad.1592807
PMCID: PMC2049196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pin1 modulates RNA polymerase II activity during the transcription cycle.PMID 18006688Read ↗

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.Semantic proximity Read ↗

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.Semantic proximity Read ↗

Therapeutic Targeting of the General RNA Polymerase II Transcription MachinerySemantic proximity Read ↗

The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses.Semantic proximity Read ↗

PAF1C allosterically activates CDK12/13 kinase during RNAPII transcript elongationSemantic proximity Read ↗

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcriptionSemantic proximity Read ↗

High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8.Semantic proximity Read ↗

Pin1 acts catalytically to promote a conformational change in Cdc25.Semantic proximity Read ↗

Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networksSemantic proximity Read ↗

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase IISemantic proximity Read ↗

Rat1p maintains RNA polymerase II CTD phosphorylation balance.Semantic proximity Read ↗

Cep55 stabilization is required for normal execution of cytokinesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.