Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.

PLoS genetics - 1 Oct 2015

Aristizabal Maria J, Negri Gian Luca, Kobor Michael S

Abstract excerpt

RNA polymerase II (RNAPII) contains a unique C-terminal domain that is composed of heptapeptide repeats and which plays important regulatory roles during gene expression. RNAPII is responsible for the transcription of most protein-coding genes, a subset of non-coding genes, and retrotransposons. Retrotransposon transcription is the first step in their multiplication cycle, given that the RNA intermediate is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Complementary
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Retroelements

Share to RNA-Binding Proteins

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26496706
DOI: 10.1371/journal.pgen.1005608
PMCID: PMC4619828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.PMID 26496706Read ↗

Retrotransposon life cycle and its impacts on cellular responsesSemantic proximity Read ↗

Novel transcript truncating function of Rap1p revealed by synthetic codon-optimized Ty1 retrotransposon.Semantic proximity Read ↗

Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation.Semantic proximity Read ↗

The initiation of epigenetic silencing of active transposable elements is triggered by RDR6 and 21-22 nucleotide small interfering RNAs.Semantic proximity Read ↗

High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8.Semantic proximity Read ↗

Integrator loss leads to dsRNA formation that triggers the integrated stress response.Semantic proximity Read ↗

Maelstrom Represses Canonical Polymerase II Transcription within Bi-Directional piRNA Clusters in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

<i>putzig</i> safeguards genome integrity by contributing to the Piwi-mediated repression of transposon activity in the female germline of <i>Drosophila</i> in a two-tiered fashionSemantic proximity Read ↗

Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells.Semantic proximity Read ↗

The Take and Give Between Retrotransposable Elements and their HostsSemantic proximity Read ↗

Evolutionary diversity and taxon-specific modifications of the RNA polymerase II C-terminal domain.Semantic proximity Read ↗

Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.