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Article

The C-terminal domain of RNA polymerase II is modified by site-specific methylation.

Science (New York, N.Y.) - 1 Apr 2011

Sims Robert J, Rojas Luis Alejandro, Beck David B, Bonasio Roberto, Schüller Roland, Drury William J, Eick Dirk, Reinberg Danny

Abstract excerpt

The carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII) in mammals undergoes extensive posttranslational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the coactivator-associated arginine methyltransferase 1 (CARM1). Although methylation at R1810 is present on the hyperphosphorylated form of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21454787
DOI: 10.1126/science.1202663
PMCID: PMC3773223

Genes

CARM1

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