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Article

Sub1 contacts the RNA polymerase II stalk to modulate mRNA synthesis.

Nucleic acids research - 17 Mar 2017

Garavís Miguel, González-Polo Noelia, Allepuz-Fuster Paula, Louro Jaime Alegrio, Fernández-Tornero Carlos, Calvo Olga

Abstract excerpt

Biogenesis of messenger RNA is critically influenced by the phosphorylation state of the carboxy-terminal domain (CTD) in the largest RNA polymerase II (RNAPII) subunit. Several kinases and phosphatases are required to maintain proper CTD phosphorylation levels and, additionally, several other proteins modulate them, including Rpb4/7 and Sub1. The Rpb4/7 heterodimer, constituting the RNAPII stalk, promote...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27924005
DOI: 10.1093/nar/gkw1206
PMCID: PMC5389574

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