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Article

Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.

Nucleic acids research - 2 Nov 2016

Inada Maki, Nichols Robert J, Parsa Jahan-Yar, Homer Christina M, Benn Ruby A, Hoxie Reyal S, Madhani Hiten D, Shuman Stewart, Schwer Beate, Pleiss Jeffrey A

Abstract excerpt

Eukaryotic gene expression requires that RNA Polymerase II (RNAP II) gain access to DNA in the context of chromatin. The C-terminal domain (CTD) of RNAP II recruits chromatin modifying enzymes to promoters, allowing for transcription initiation or repression. Specific CTD phosphorylation marks facilitate recruitment of chromatin modifiers, transcriptional regulators, and RNA processing factors during the...

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Identifiers

PMID: 27402158
DOI: 10.1093/nar/gkw603
PMCID: PMC5100562

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.PMID 27402158Read ↗

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