Article
Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.
Mitochondrion - 1 Nov 2013
Takibuchi Gaku, Imanishi Hirotake, Morimoto Mami, Ishikawa Kaori, Nakada Kazuto, Toyama-Sorimachi Noriko, Kikkawa Yoshiaki, Takenaga Keizo, Hayashi Jun-Ichi
Abstract excerpt
To examine whether polymorphic mtDNA mutations that do not induce significant respiration defects regulate phenotypes of tumor cells, we used mouse transmitochondrial tumor cells (cybrids) with nuclear DNA from C57BL/6 (B6) strain and mtDNA from allogenic C3H strain. The results showed that polymorphic mutations of C3H mtDNA in the cybrids induced hypoxia sensitivity, resulting in a delay of tumor formation on...
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