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Article

Somatic alterations in mitochondrial DNA produce changes in cell growth and metabolism supporting a tumorigenic phenotype.

Biochimica et biophysica acta - 1 Feb 2012

Jandova Jana, Shi Mingjian, Norman Kimberly G, Stricklin George P, Sligh James E

Abstract excerpt

There have been many reports of mitochondrial DNA (mtDNA) mutations associated with human malignancies. We have observed allelic instability in UV-induced cutaneous tumors at the mt-Tr locus encoding the mitochondrial tRNA for arginine. We examined the effects of somatic alterations at this locus by modeling the change in a uniform nuclear background by generating cybrids harboring allelic variation at mt-Tr. We...

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Identifiers

PMID: 22119597
DOI: 10.1016/j.bbadis.2011.11.010
PMCID: PMC3249529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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