Article
Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system.
PloS one - 1 Jan 2013
Imanishi Hirotake, Takibuchi Gaku, Kobayashi Toshihiko, Ishikawa Kaori, Nakada Kazuto, Mori Masayuki, Kikkawa Yoshiaki, Takenaga Keizo, Toyama-Sorimachi Noriko, Hayashi Jun-Ichi
Abstract excerpt
In mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glycolysis under normoxic conditions (the Warburg effects). However, because both nuclear DNA and mtDNA control mitochondrial respiratory function, it is difficult to exclude the possible contribution of nuclear DNA...
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