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Article

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Science (New York, N.Y.) - 2 May 2008

Ishikawa Kaori, Takenaga Keizo, Akimoto Miho, Koshikawa Nobuko, Yamaguchi Aya, Imanishi Hirotake, Nakada Kazuto, Honma Yoshio, Hayashi Jun-Ichi

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) occur at high frequency in human tumors, but whether these mutations alter tumor cell behavior has been unclear. We used cytoplasmic hybrid (cybrid) technology to replace the endogenous mtDNA in a mouse tumor cell line that was poorly metastatic with mtDNA from a cell line that was highly metastatic, and vice versa. Using assays of metastasis in mice, we found that the...

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Identifiers

PMID: 18388260
DOI: 10.1126/science.1156906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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