Article
Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.
Human molecular genetics - 15 Mar 2006
Kasahara Atsuko, Ishikawa Kaori, Yamaoka Makiko, Ito Masahito, Watanabe Naoki, Akimoto Miho, Sato Akitsugu, Nakada Kazuto, Endo Hitoshi, Suda Yoko, Aizawa Shinichi, Hayashi Jun-Ichi
Abstract excerpt
Generation of various kinds of trans-mitochondrial mice, mito-mice, each carrying mtDNAs with a different pathogenic mutation, is required for precise investigation of the pathogenesis of mitochondrial diseases. This study used two respiration-deficient mouse cell lines as donors of mtDNAs with possible pathogenic mutations. One cell line expressed 45-50% respiratory activity due to mouse mtDNAs with a T6589C...
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