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Article

Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner.

Cancer research - 1 Mar 2020

Brinker Amanda E, Vivian Carolyn J, Beadnell Thomas C, Koestler Devin C, Teoh Shao Thing, Lunt Sophia Y, Welch Danny R

Abstract excerpt

Mitochondria contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calcium signaling, and apoptosis. Using the Mitochondrial Nuclear Exchange (MNX) mouse models, which pair nuclear genomes with different mitochondrial genomes, we previously showed that mitochondrial SNPs regulate mammary carcinoma tumorigenicity and metastatic potential in genetic crosses. Here, we tested...

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Identifiers

PMID: 31848195
DOI: 10.1158/0008-5472.CAN-19-2481
PMCID: PMC7056497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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